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This is not harmful and will subside in about 20 to 30 minutes. It is methylation that is severely disrupted in those with C677T MTHFR mutations – especially homozygous individuals. If methylation becomes excessive, side effects will occur as noted above. There is a need for routine adjustment as our bodies are dynamic.

The MTHFR enzyme is working at nearly 70% or so effectiveness in heterozygous individuals while in homozygous individuals, it is working at only 30% effectiveness (The effectiveness percentage varies from paper to paper. Individuals who are homozygous for the C677T MTHFR mutation do need more methylfolate than what is in the Optimal Multivitamin line.NOTE: If you begin supplementing with methylfolate and you have inflammation unchecked, your symptoms may worsen.There are other steps that must be taken prior to supplementing with methylfolate if these side effects occur.If side effects occur, taking Niacin helps bind the excessive methyl groups which are likely causing the issue.In general, those with C677T mutations have decreased ability to produce methylfolate, increased cardiovascular risk, increased risk of blood clots, increased pain and inflammation and increased chemical sensitivity.

Recommendations below support the reduction of these issues by increasing the body’s inherent ability to restore function through nutritional biochemistry.They are not flat out must-haves nor must one take all of them.—I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.Some of these recommendations require a full explanation.Regardless of MTHFR or not, the recommendations for diet, lifestyle and environment need to be considered by all!Now – the supplement recommendations need to be tailored to the individual – again – regardless of which genetic variants you have.Talk with your physician before altering any protocol or supplement/pharmaceutical.