The same year he was cast in Michael Bay's science fiction film Transformers as Sam Witwicky, the main protagonist of the series.
La Beouf later worked with Cudi and Cage on a short film inspired by their collaborative "Maniac", from Cudi's second album Man on the Moon II: The Legend of Mr. Aside from directing the short film, which was titled Maniac (2011), La Beouf directed the music video for Kid Cudi's song "Marijuana", which he filmed at the 2010 Cannabis Cup.
La Beouf said production was only delayed two days after his accident because Bay made up for it by filming second unit scenes, and La Beouf recovered a few weeks earlier than expected, allowing him to return to the set.
In 2012, Rob Cantor of Tally Hall produced a song describing La Beouf as a murderous cannibal.
In 2014, Cantor produced a music video based on this song.
In 2016, La Beouf starred in American Honey, directed by Andrea Arnold, playing the male lead role, Jake.
In Variety, Guy Lodge wrote that "despite the apparent stunt casting of La Beouf", he "easily delivers his best performance here, bleeding the eccentricities of his own celebrity persona into the character to fascinating, oddly moving effect".Despite the title and lyrics, the intent was humorous and non-serious, and La Beouf appeared at the end of the video, applauding.La Beouf has created three short graphic novels Stale N Mate, Cyclical, and Let's Fucking Party, and a webcomic series, Cheek Up's through the publishing company, The Campaign Book.Since then, La Beouf, Rönkkö & Turner have engaged in numerous high-profile performance art projects, including #IAMSORRY (2014), #INTRODUCTIONS (2015), #ALLMYMOVIES (2015), #TOUCHMYSOUL (2015), #TAKEMEANYWHERE (2016), and HEWILLNOTDIVIDE. In November 2014, La Beouf stated that a woman had "stripped [his] clothing and proceeded to rape [him]" the previous February during the trio's #IAMSORRY performance in Los Angeles, In response to Piers Morgan's questions on Twitter as to why the woman was not detained, Turner stated that she ran out before it was clear precisely what had happened, and that the first priority had been to ensure everybody's safety in the gallery.When later asked whether they regretted not having a code of conduct for participants during the exhibit, Turner said, "I don’t think you need a notice on the wall saying 'Do not murder the artist'." On June 26, 2014, La Beouf was charged with disorderly conduct and criminal trespass at New York's Studio 54 theater.In April 2012, he promoted them at Chicago Comic & Entertainment Expo.