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The organism requires minimal set of functional genes for its survival. Bateman A, Birney E, Cerruti L (2002).‖The Pfam Protein Families Database‖. Two kinds of improved evolution rules are proposed to replace the rule in regular cellular genetic algorithm, in which null cells are considered to the foods of individuals in population and the maximum of living individuals in cellular space is limited by their food. This infectious disease results in Leprosy reactions that cause irreversible nerve damage and disabilities. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997) Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. In: Proceedings of the ACM/IEEE Conference on Supercomputing (SC06), Nov 11–17, Florida. Chemotherapy of leprosy for control programs- report of WHO study (2004). In this paper, we advanced two kinds of cellular genetic algorithms inspired by the density dependence scheme in ecological system to solving dynamic optimization problems.

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Biologically inspired evolutionary agent systems in dynamic environments.

Diversity-based model reference for genetic algorithms in dynamic environment.

The bacteria have developed resistance against many of the drugs available in the market.

Halgamuge "Self-Organizing Hierarchical Particle Swarm Optimizer With Time Varying Acceleration Coefficients" IEEE Trans. A well organized research comprising of analogue based drug design and molecular dynamics plays a major role in obtaining the lead molecules. Black PN, Di Russo CC, Metzger AK, Heimert TL (1992): Cloning, sequencing, and expression of the fad D gene of Escherichia coli encoding Acyl coenzyme A Synthetase.

Stukenbrock, "Toward maximum flexibility in working machinery, iht control in a mecalac excavator," 2004. Yao, "Energy-saving control of singlerod hydraulic cylinders with programmable valves and improved working mode selection," 2002. Eriksson, "Control Strategy for Energy Efficient Fluid Power Actuators: Utilizing Individual Metering," SE-581 83 Linköping, Sweden: Linköping University, 2007. There are various field of power system in which PSO is successfully applied.

(April 2003), "Nanometer stepping drives of surface acoustic wave motor", IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 50, IEEE, pp. Due to its higher quality solution including mathematical simplicity, fast convergence & robustness it has become popular for many optimization problems. Abstract: Particle swarm optimization (PSO ) is an effective & reliable evolutionary based approach . Yuhui Shi and Russell Eberhart "A modified particle swarm optimizer" 0- 7803-4869-9198 0.0001998 IEEE. Eberhart "Fuzzy Adaptive Particle Swarm Optimization" Evolutionary computation, 2001 proceeding of the 2001 congres on vol.1 page no. Gaing, "Particle Swarm Optimization to solving the economic dispatch considering generator constraints," IEEE Trans. The proposed four ports cylinder was simulated and parameters such as ports sizes, loads and pressures are varied during the simulation.